Making sense of Dlx1 antisense RNA

Making sense of antisense therapy for hypertension.

ed in the regulation of vascular tone. Whilst pharmacological antagonism of ‚-adrenoceptors is still part of the mainstay treatment for hypertension, ·adrenoreceptor blockade is rarely used as a front line therapy. In the ALLHAT study peripheral ·-blockade in high risk hypertensive patients led to a 25% increase in cardiovascular events and doubled the likelihood of hospital admissions. Althoug...

Making sense (and antisense) of the X inactivation center.

T concept of the X inactivation center (Xic) as the master regulatory locus for X inactivation dates back to the mid1960s (1, 2), not long after X chromosome inactivation itself was proposed as the mammalian dosage compensation mechanism (3–5). Defined genetically as the cis-acting locus required for an X chromosome to undergo inactivation early in female embryogenesis, the Xic defied molecular...

Intergenic Antisense MHC Gene Regulation 1 Making Sense (and Antisense) of Myosin Heavy Chain Gene Expression

Detection of a novel sense-antisense RNA-hybrid structure by RACE experiments on endogenous troponin I antisense RNA.

Conformational changes in the troponin/tropomyosin complex significantly alter the mechanical properties of cardiac muscle. Phosphorylation of cardiac troponin I, part of the troponin/tropomyosin complex, reduces calcium affinity, which leads to increased relaxation of cardiac muscle. Because cardiac troponin I plays a central role in tuning the heart to different work demands, detailed knowled...

Antisense Translates into Sense

T he paradigm that DNA is the central bank of genetic information within the cell, and that portions of the DNA are copied via transcription to RNA, which is subsequently decoded to synthesize protein in a cell, is basically true throughout cellular evolution. However, it is also true that although this is a general blueprint for regulating how genes are expressed, evolution, with its varied se...